Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 3/20 | 0.60 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.54 |
| ▸ | CCR2 | P41597 | 2/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CFTR | P13569 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6086406 | 0.88 | MEN1 (0.56) | ARCCR2MEN1KMT2AGAA | |
| SCHEMBL27361127 | 0.87 | PKM (0.53) | ARCYP19A1MEN1KMT2AL3MBTL1 | |
| SCHEMBL11616337 | 0.85 | CCR2 (0.57) | ARPLA2G2ACCR2CYP19A1CFTR | |
| SCHEMBL6611835 | 0.82 | CYP1A2 (0.50) | ARCCR2CYP19A1MEN1KMT2A | |
| SCHEMBL15712743 | 0.82 | CCR2 (0.77) | PLA2G2ACCR2 | |
| SCHEMBL2965240 | 0.81 | CFTR (0.50) | PLA2G2ACCR2CFTR | |
| SCHEMBL17060318 | 0.80 | NOD2 (0.60) | ARPLA2G2ACCR2MEN1KMT2A | |
| SCHEMBL1252366 | 0.80 | CCR2 (0.51) | PLA2G2ACCR2CYP19A1MEN1KMT2A | |
| SCHEMBL27532542 | 0.79 | PLA2G2A (0.50) | ARPLA2G2ACCR2CYP19A1MEN1 | |
| SCHEMBL31441369 | 0.79 | MEN1 (0.71) | MEN1KMT2AGAARAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6252084-B1 | THERAPY FOR SEPSIS SHOCK | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| EP-0620215-B1 | 1H-indole-3-acetamide derivatives as sPLA2 inhibitors | LILLY CO ELI (US) | 1999-08-18 | — | — | EP | disclosed |
| US-5684034-A | INHIBITORS OF HUMAN NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2, TREATMENT OF SEPTIC SHOCK, TRAUMA, RESPIRATORY DISORDERS, RHEUMATIC ARTHRITIS, INHIBITORS OF ARACHIDONIC ACID RELEASE | ELI LILLY AND COMPANY (US) | 1997-11-04 | — | — | US | disclosed |
| EP-0620215-A1 | 1H-indole-3-acetamide derivatives as sPLA2 inhibitors | ELI LILLY AND COMPANY (US) | 1994-10-19 | — | — | EP | disclosed |