Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | CASP1 | P29466 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12299575 | 0.87 | GPR88 (0.36) | BACE1CTSDALDH1A1 | |
| SCHEMBL7958731 | 0.85 | FADS1 (0.37) | BACE1CTSD | |
| SCHEMBL7962017 | 0.82 | KDM4E (0.32) | KDM4EMAPT | |
| SCHEMBL882888 | 0.73 | BACE1 (0.43) | BACE1CTSD | |
| SCHEMBL7947839 | 0.71 | KDM4E (0.32) | KDM4EMAPT | |
| SCHEMBL7891697 | 0.68 | BACE1 (0.38) | BACE1CTSD | |
| SCHEMBL12827653 | 0.67 | BACE1 (0.40) | BACE1 | |
| SCHEMBL7957152 | 0.62 | BACE1 (0.62) | BACE1CTSD | |
| SCHEMBL1821500 | 0.62 | BACE1 (0.62) | BACE1CTSD | |
| SCHEMBL882560 | 0.62 | BACE1 (0.37) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010021680-A2 | INHIBITORS OF BETA-SECRETASE | VITAE PHARMACEUTICALS, INC. (US) | 2010-02-25 | — | — | WO | disclosed |