Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 8/20 | 0.43 |
| ▸ | CTSD | P07339 | 6/20 | 0.43 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.31 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.31 |
| ▸ | PRKACA | P17612 | 1/20 | 0.30 |
| ▸ | PRKACG | P22612 | 1/20 | 0.30 |
| ▸ | PRKACB | P22694 | 1/20 | 0.30 |
| ▸ | F2R | P25116 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12299575 | 0.75 | GPR88 (0.36) | BACE1CTSDDPP4DPP8DPP9 | |
| SCHEMBL882560 | 0.74 | BACE1 (0.37) | BACE1 | |
| SCHEMBL7958731 | 0.73 | FADS1 (0.37) | BACE1CTSDMCHR1DPP4DPP8 | |
| SCHEMBL7962464 | 0.73 | BACE1 (0.33) | BACE1CTSD | |
| SCHEMBL7891697 | 0.69 | BACE1 (0.38) | BACE1CTSD | |
| SCHEMBL882893 | 0.69 | BACE1 (0.36) | BACE1CTSD | |
| SCHEMBL882992 | 0.67 | CTSD (0.31) | BACE1CTSD | |
| SCHEMBL12827653 | 0.67 | BACE1 (0.40) | BACE1DPP4DPP8DPP9DPP7 | |
| SCHEMBL882550 | 0.66 | BACE1 (0.45) | BACE1CTSD | |
| SCHEMBL882648 | 0.66 | BACE1 (0.35) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012040641-A2 | COMPOUNDS FOR TREATING NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2012-03-29 | — | — | WO | disclosed |