Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 2/20 | 0.52 |
| ▸ | CSF1R | P07333 | 4/20 | 0.47 |
| ▸ | KDR | P35968 | 7/20 | 0.46 |
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | KDM1A | O60341 | 2/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 2/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.44 |
| ▸ | KIF5B | P33176 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | MET | P08581 | 1/20 | 0.43 |
| ▸ | TEK | Q02763 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7982589 | 0.83 | CSF1R (0.57) | TRPA1CSF1RKDREGFRPDGFRB | |
| SCHEMBL7214444 | 0.77 | KDR (0.63) | CSF1RKDREGFRKDM1APDGFRB | |
| SCHEMBL8204598 | 0.75 | CSF1R (0.47) | TRPA1CSF1RKDREGFRKDM1A | |
| SCHEMBL5825666 | 0.75 | CSF1R (0.62) | TRPA1CSF1RKDREGFRKDM1A | |
| SCHEMBL4497789 | 0.71 | KDM1A (0.38) | CSF1RKDREGFRKDM1AFLT4 | |
| SCHEMBL5676564 | 0.70 | CA2 (0.57) | PDGFRBRAB9A | |
| SCHEMBL31252794 | 0.70 | CA2 (0.57) | PDGFRBRAB9A | |
| SCHEMBL10296330 | 0.70 | ENPP1 (0.55) | TRPA1CSF1RKDREGFRKDM1A | |
| SCHEMBL13763602 | 0.69 | TRPA1 (0.62) | TRPA1CSF1REGFRPDGFRBFLT4 | |
| SCHEMBL5825352 | 0.69 | PDGFRB (0.74) | CSF1RKDREGFRPDGFRBFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6184225-B1 | ENDOTHELIAL GROWTH FACTOR INHIBITORS, ANGIOGENESIS INHIBITORS | ZENECA LIMITED (GB) | 2001-02-06 | — | — | US | disclosed |