Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 7/20 | 0.36 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.35 |
| ▸ | CHRNB3 | Q05901 | 2/20 | 0.35 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | CYP21A2 | P08686 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | FPR1 | P21462 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8328200 | 0.92 | CHRNB1 (0.35) | CYP11B2CHRNB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL2157354 | 0.91 | MKNK1 (0.39) | CYP11B2CHRNB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL7965546 | 0.91 | NR4A2 (0.40) | CYP11B2CHRNB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL7967732 | 0.86 | CYP11B2 (0.39) | CYP11B2CHRNB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL7965050 | 0.82 | CYP2C19 (0.33) | CYP2C19ALDH1A1POLB | |
| SCHEMBL2157391 | 0.81 | CYP11B2 (0.40) | CYP11B2CHRNB1CHRNB2CHRNB4CHRNA3 | |
| SCHEMBL7965681 | 0.80 | FPR1 (0.33) | FPR1FPR2 | |
| SCHEMBL7962101 | 0.80 | NR4A2 (0.40) | CYP11B2NR4A2CYP11B1CYP19A1FPR1 | |
| SCHEMBL7954864 | 0.77 | CYP11B2 (0.42) | CYP11B2P2RX7CYP11B1CYP3A4CYP2A6 | |
| SCHEMBL8325325 | 0.77 | CYP11B2 (0.39) | CYP11B2CYP2C9KCNH2FPR1FPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | claimed |
| US-6207675-B1 | FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA | RHONE-POULENC RORER S.A. (FR) | 2001-03-27 | — | — | US | disclosed |