SCHEMBL7965050

SCHEMBL7965050

COC1CCCn2c(-c3cccnc3Cl)c(Cl)c(C(C)=O)c21

nearest known ligand 0.36

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP2C19 P33261 1/20 0.33
HCRTR1 O43613 2/20 0.32
HCRTR2 O43614 1/20 0.32
FAAH O00519 3/20 0.32
DHODH Q02127 1/20 0.31
POLB P06746 1/20 0.31
AVPR2 P30518 1/20 0.31
AVPR1A P37288 1/20 0.31
ALDH1A1 P00352 2/20 0.31
PER2 O15055 1/20 0.31
TBXA2R P21731 1/20 0.31
PTGDR Q13258 1/20 0.31
PDE4B Q07343 1/20 0.31
DPP4 P27487 1/20 0.30
DRD4 P21917 1/20 0.30
MAPK1 P28482 1/20 0.30
JAK2 O60674 1/20 0.30
JAK3 P52333 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8326401 0.92 DHODH (0.37) CYP2C19HCRTR1HCRTR2FAAHDHODH
SCHEMBL7962835 0.91 ALDH1A1 (0.33) CYP2C19HCRTR1HCRTR2FAAHDHODH
SCHEMBL7961198 0.91 MEN1 (0.34) CYP2C19ALDH1A1PDE4B
SCHEMBL7965681 0.90 FPR1 (0.33) HCRTR1DHODHPER2TBXA2RPTGDR
SCHEMBL7965010 0.86 HCRTR1 (0.33) CYP2C19HCRTR1HCRTR2FAAHDHODH
SCHEMBL8330797 0.82 DHODH (0.36) HCRTR1DHODHPER2PDE4B
SCHEMBL7962938 0.82 CYP11B2 (0.36) CYP2C19POLBALDH1A1
SCHEMBL7961758 0.81 FPR1 (0.35) HCRTR1ALDH1A1PDE4BJAK3
SCHEMBL7961641 0.81 BACE1 (0.34) HCRTR1DHODHPER2PDE4B
SCHEMBL7961100 0.80 DPP4 (0.33) DPP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6207675-B1 FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA RHONE-POULENC RORER S.A. (FR) 2001-03-27 US claimed
US-6207675-B1 FOR PROPHYLAXIS AND THERAPY OF DISEASES IN WHICH ARE INVOLVED VIRUSES OF THE HERPES FAMILY AND/OR CYTOKINES IN PARTICULAR TUMOR NERCOSIS FACTOR-ALPHA RHONE-POULENC RORER S.A. (FR) 2001-03-27 US disclosed
EP-0946555-A1 PYRROLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Aventis Pharma S.A. (FR) 1999-10-06 EP disclosed
WO-1998025925-A1 PYRROLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM RHONE-POULENC RORER S.A. (FR) 1998-06-18 WO disclosed