Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 4/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 11/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8139378 | 0.91 | SLC6A1 (0.34) | OPRL1OPRM1OPRD1HTR1ADRD2 | |
| SCHEMBL7963100 | 0.91 | SLC6A1 (0.34) | OPRL1OPRM1OPRD1HTR1ADRD2 | |
| SCHEMBL7965454 | 0.87 | OPRL1 (0.36) | OPRL1OPRM1HTR1ACCR1 | |
| SCHEMBL7967096 | 0.83 | TUBB4A (0.38) | OPRL1OPRM1OPRD1 | |
| SCHEMBL7962997 | 0.82 | CYP2D6 (0.50) | HTR1A | |
| Bromide SCHEMBL7965944 | 0.81 | OPRM1 (0.36) | OPRL1OPRM1OPRD1 | |
| SCHEMBL7962994 | 0.80 | DRD2 (0.38) | OPRL1OPRM1OPRD1DRD2 | |
| SCHEMBL7964906 | 0.79 | OPRL1 (0.46) | OPRL1OPRM1OPRD1HTR1ADRD2 | |
| SCHEMBL7965744 | 0.76 | HTR1A (0.36) | HTR1ADRD2 | |
| SCHEMBL7965345 | 0.75 | SLC6A1 (0.34) | OPRL1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |