Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 8/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963269 | 0.85 | SLC6A2 (0.33) | — | |
| SCHEMBL7963263 | 0.85 | — | — | |
| SCHEMBL7965342 | 0.77 | KMT2A (0.44) | SMN1; SMN2NPC1HPGDRAB9AABCB1 | |
| SCHEMBL7953974 | 0.77 | HTR1A (0.41) | SMN1; SMN2NPC1HPGDRAB9AABCB1 | |
| SCHEMBL7965451 | 0.75 | SMN1; SMN2 (0.55) | SMN1; SMN2NPC1HPGDRAB9AMEN1 | |
| SCHEMBL7965741 | 0.74 | HTR1A (0.54) | HTR1ACYP1A2CYP2C19 | |
| SCHEMBL7967123 | 0.73 | ABCB1 (0.58) | ABCB1 | |
| Malonic Acid SCHEMBL7953260 | 0.73 | MAPT (0.44) | SMN1; SMN2ABCB1LMNAMAPTHTR1A | |
| SCHEMBL7963099 | 0.72 | KMT2A (0.49) | SMN1; SMN2MEN1KMT2AMAPTKDM4E | |
| SCHEMBL7967094 | 0.72 | HTR7 (0.54) | SMN1; SMN2LMNAMAPTMAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |