Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.31 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.31 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.31 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963266 | 0.85 | SMN1; SMN2 (0.39) | — | |
| SCHEMBL7963263 | 0.84 | — | — | |
| SCHEMBL7965345 | 0.77 | SLC6A1 (0.34) | SLC6A2SLC6A4SLC6A1SLC6A12SLC6A11 | |
| SCHEMBL7953976 | 0.77 | SLC6A2 (0.38) | SLC6A2SLC6A4SLC6A1SLC6A12SLC6A11 | |
| SCHEMBL7965454 | 0.75 | OPRL1 (0.36) | SLC6A1SLC6A12SLC6A11SLC6A13OPRM1 | |
| SCHEMBL7965744 | 0.74 | HTR1A (0.36) | SLC6A4SLC6A1SLC6A12SLC6A11SLC6A13 | |
| SCHEMBL7967126 | 0.73 | ABCB1 (0.39) | — | |
| SCHEMBL7963100 | 0.72 | SLC6A1 (0.34) | SLC6A2SLC6A4SLC6A1SLC6A12SLC6A11 | |
| SCHEMBL8139378 | 0.72 | SLC6A1 (0.34) | SLC6A2SLC6A4SLC6A1SLC6A12SLC6A11 | |
| SCHEMBL7967096 | 0.72 | TUBB4A (0.38) | SLC6A1SLC6A12SLC6A11SLC6A13OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| WO-2000006166-A1 | 5-HT1F ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |