Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 5/20 | 0.51 |
| ▸ | BCHE | P06276 | 4/20 | 0.51 |
| ▸ | BACE1 | P56817 | 3/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27630402 | 0.86 | DRD2 (0.71) | DRD2KMT2AMEN1ACHEBACE1 | |
| SCHEMBL4826023 | 0.85 | DRD2 (1.00) | DRD2KMT2AMEN1SIGMAR1 | |
| SCHEMBL7966838 | 0.84 | DRD2 (0.58) | DRD2KMT2AMEN1SLC6A4ACHE | |
| SCHEMBL7965742 | 0.82 | SIGMAR1 (0.57) | DRD2KMT2AMEN1SLC6A4ACHE | |
| SCHEMBL7965603 | 0.81 | DRD2 (0.54) | DRD2KMT2AMEN1SLC6A4ACHE | |
| SCHEMBL1002852 | 0.77 | MEN1 (0.81) | DRD2KMT2AMEN1ACHESIGMAR1 | |
| SCHEMBL7965426 | 0.76 | DRD2 (0.53) | DRD2KMT2AMEN1SLC6A4 | |
| SCHEMBL9070278 | 0.75 | MEN1 (0.67) | DRD2KMT2AMEN1ACHESIGMAR1 | |
| SCHEMBL7571134 | 0.75 | MEN1 (0.88) | DRD2KMT2AMEN1ACHEBCHE | |
| SCHEMBL62398 | 0.74 | DRD4 (0.85) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| WO-1999065487-A1 | INHIBITORS OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |