Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | CCR5 | P51681 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 6/20 | 0.51 |
| ▸ | BACE1 | P56817 | 4/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.49 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.49 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8641021 | 0.86 | ACHE (0.46) | DRD2KMT2AMEN1ACHE | |
| SCHEMBL11453030 | 0.86 | POLB (0.67) | DRD2LMNAPOLBKMT2AMEN1 | |
| SCHEMBL7965742 | 0.84 | SIGMAR1 (0.57) | DRD2SLC6A4KMT2AMEN1ACHE | |
| SCHEMBL7963379 | 0.84 | DRD2 (0.73) | DRD2SLC6A4KMT2AMEN1ACHE | |
| SCHEMBL7965603 | 0.81 | DRD2 (0.54) | DRD2SLC6A4KMT2AMEN1CCR5 | |
| SCHEMBL25890035 | 0.79 | ACHE (0.60) | LMNAPOLBKMT2AMEN1CCR5 | |
| SCHEMBL22642807 | 0.78 | DRD2 (0.58) | DRD2KMT2AMEN1CCR5ACHE | |
| SCHEMBL27324146 | 0.78 | DRD2 (0.58) | DRD2LMNAPOLBKMT2AMEN1 | |
| SCHEMBL17432875 | 0.78 | MEN1 (0.61) | DRD2LMNAPOLBKMT2AMEN1 | |
| SCHEMBL1002852 | 0.77 | MEN1 (0.81) | DRD2KMT2AMEN1CCR5ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| WO-1999065487-A1 | INHIBITORS OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |