Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.57 |
| ▸ | DRD2 | P14416 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | ACHE | P22303 | 3/20 | 0.55 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | BACE1 | P56817 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8641021 | 0.88 | ACHE (0.46) | SIGMAR1DRD2MEN1KMT2AACHE | |
| SCHEMBL28172286 | 0.88 | SIGMAR1 (0.69) | SIGMAR1DRD2MEN1KMT2AACHE | |
| SCHEMBL7966838 | 0.84 | DRD2 (0.58) | DRD2MEN1KMT2AACHESLC6A4 | |
| SCHEMBL7963379 | 0.82 | DRD2 (0.73) | SIGMAR1DRD2MEN1KMT2AACHE | |
| SCHEMBL6360566 | 0.81 | SIGMAR1 (0.63) | SIGMAR1DRD2MEN1KMT2AACHE | |
| SCHEMBL7965426 | 0.81 | DRD2 (0.53) | DRD2MEN1KMT2ACHRM4SLC6A4 | |
| SCHEMBL22928142 | 0.81 | DRD2 (0.62) | SIGMAR1DRD2MEN1KMT2AACHE | |
| SCHEMBL6353029 | 0.81 | DRD2 (0.62) | SIGMAR1DRD2MEN1KMT2AACHE | |
| SCHEMBL925814 | 0.79 | KMT2A (0.60) | SIGMAR1MEN1KMT2AACHEBACE1 | |
| SCHEMBL7965603 | 0.79 | DRD2 (0.54) | DRD2MEN1KMT2AACHESLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303627-B1 | FOR THERAPY OF PHYSIOLOGICAL AND PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY | 2001-10-16 | — | — | US | disclosed |
| WO-1999065487-A1 | INHIBITORS OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |
| EP-0965587-A1 | Tetrahydropyridinyl- and piperidinyl Inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |