Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 6/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7961484 | 0.90 | SIGMAR1 (0.55) | HTR1ASIGMAR1DRD2 | |
| SCHEMBL7961371 | 0.90 | SIGMAR1 (0.50) | HTR1ASIGMAR1DRD2MAPT | |
| SCHEMBL7964085 | 0.90 | SIGMAR1 (0.55) | HTR1ASIGMAR1PARP1DRD2HTR7 | |
| SCHEMBL7957217 | 0.89 | SIGMAR1 (0.52) | HTR1ASIGMAR1PARP1 | |
| SCHEMBL7961332 | 0.85 | HTR1A (0.53) | HTR1ASIGMAR1PARP1DRD2HTR7 | |
| SCHEMBL7959610 | 0.84 | SIGMAR1 (0.48) | HTR1ASIGMAR1DRD2 | |
| SCHEMBL7963865 | 0.84 | SIGMAR1 (0.46) | HTR1ASIGMAR1DRD2KDM4EHTR7 | |
| SCHEMBL7957391 | 0.83 | HTR7 (0.47) | HTR1ASIGMAR1PARP1DRD2KDM4E | |
| SCHEMBL7949420 | 0.81 | HTR6 (0.43) | HTR1ASIGMAR1DRD2HTR7MAPT | |
| SCHEMBL7963788 | 0.81 | SIGMAR1 (0.52) | HTR1ASIGMAR1PARP1DRD2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |