SCHEMBL7963893

SCHEMBL7963893

C=CCn1cccc1CC(=O)O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 2/20 0.43
PTGS2 P35354 2/20 0.43
NPC1 O15118 8/20 0.42
KMT2A Q03164 7/20 0.42
RAB9A P51151 7/20 0.41
MEN1 O00255 3/20 0.41
ALDH1A1 P00352 7/20 0.39
KDM4E B2RXH2 2/20 0.39
HPGD P15428 2/20 0.39
HSD17B10 Q99714 1/20 0.39
MAPT P10636 3/20 0.39
LMNA P02545 2/20 0.39
ALOX12 P18054 1/20 0.39
RECQL P46063 1/20 0.39
POLB P06746 1/20 0.39
ALOX5 P09917 1/20 0.38
SMN1; SMN2 Q16637 2/20 0.37
HTT P42858 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11241235 0.85 NPC1 (0.41) NPC1KMT2ARAB9AMEN1ALDH1A1
SCHEMBL7675118 0.78 NPC1 (0.39) NPC1KMT2ARAB9AMEN1ALDH1A1
SCHEMBL11352735 0.77 PTGS2 (0.46) PTGS1PTGS2KMT2AMEN1ALDH1A1
SCHEMBL1655684 0.76 ALOX5 (0.39) NPC1KMT2ARAB9AMEN1ALDH1A1
SCHEMBL4739140 0.75 KMT2A (0.45) NPC1KMT2ARAB9AMEN1ALDH1A1
SCHEMBL11366434 0.74 PTGS1 (0.44) PTGS1PTGS2NPC1KMT2ARAB9A
SCHEMBL12951910 0.74 AKR1B1 (0.50) PTGS1PTGS2RAB9AALDH1A1KDM4E
SCHEMBL11358391 0.72 PTGS2 (0.43) PTGS1PTGS2KMT2AMEN1ALDH1A1
SCHEMBL3720066 0.71 GAA (0.38) NPC1KMT2ARAB9AMEN1ALDH1A1
SCHEMBL5056802 0.71 NPC1 (0.60) NPC1KMT2ARAB9AMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6117889-A 7-Azabicyclo-[2.2.1]-heptane and -heptene derivatives as analgesics and anti-inflammatory agents UNIVERSITY OF VIRGINIA (US) 2000-09-12 US claimed
EP-0691971-A1 7-AZABICYCLO- 2.2.1]-HEPTANE AND -HEPTENE DERIVATIVES AS ANALGESICS AND ANTI-INFLAMMATORY AGENTS UNIVERSITY OF VIRGINIA (US) 1996-01-17 EP claimed
WO-1994022868-A1 7-AZABICYCLO-[2.2.1]-HEPTANE AND -HEPTENE DERIVATIVES AS ANALGESICS AND ANTI-INFLAMMATORY AGENTS UNIVERSITY OF VIRGINIA (US) 1994-10-13 WO claimed
US-6255490-B1 TREATING DISORDERS ASSOCIATED WITH CHANGES IN CHOLINERGIC ACTIVITY; NON-OPIATE BASED ANALGESIC FOR MODERATE TO SEVERE PAIN EQUALLY OR EXCEEDING THE POTENCY OF OPIATE ANALGESICS, YET LACKING ADDICTIVE SIDE EFFECTS UNIVERSITY OF VIRGINIA 2001-07-03 US disclosed
US-6117889-A 7-Azabicyclo-[2.2.1]-heptane and -heptene derivatives as analgesics and anti-inflammatory agents UNIVERSITY OF VIRGINIA (US) 2000-09-12 US disclosed
US-6060473-A 7-azabicyclo[2.2.1]-heptane and -heptene derivatives as cholinergic receptor ligands UCB S.A. - DTB (BE) 2000-05-09 US disclosed
EP-0778835-A4 7-AZABICYCLO 2.2.1]-HEPTANE AND -HEPTENE DERIVATIVES AS CHOLINERGIC RECEPTOR LIGANDS UNIV VIRGINIA (US) 1999-02-03 EP disclosed
US-5817679-A ANALGESICS, ANTIINFLAMMATORY AGENTS UNIVERSITY OF VIRGINIA (US) 1998-10-06 US disclosed
EP-0778835-A1 7-AZABICYCLO 2.2.1]-HEPTANE AND -HEPTENE DERIVATIVES AS CHOLINERGIC RECEPTOR LIGANDS UNIVERSITY OF VIRGINIA (US) 1997-06-18 EP disclosed
WO-1996006093-A1 7-AZABICYCLO[2.2.1]-HEPTANE AND -HEPTENE DERIVATIVES AS CHOLINERGIC RECEPTOR LIGANDS UNIVERSITY OF VIRGINIA (US) 1996-02-29 WO disclosed
EP-0691971-A1 7-AZABICYCLO- 2.2.1]-HEPTANE AND -HEPTENE DERIVATIVES AS ANALGESICS AND ANTI-INFLAMMATORY AGENTS UNIVERSITY OF VIRGINIA (US) 1996-01-17 EP disclosed
WO-1994022868-A1 7-AZABICYCLO-[2.2.1]-HEPTANE AND -HEPTENE DERIVATIVES AS ANALGESICS AND ANTI-INFLAMMATORY AGENTS UNIVERSITY OF VIRGINIA (US) 1994-10-13 WO disclosed
US-4528382-A Imidoyl substituted pyrroles MCNEILAB, INC. (US) 1985-07-09 US disclosed
US-4528382-A Imidoyl substituted pyrroles MCNEILAB, INC. (US) 1985-07-09 US disclosed
US-4255335-A Preparation of 5-aroyl-1-loweralkylpyrrole-2-acetic acid derivatives MCNEILAB, INC. (US) 1981-03-10 US disclosed
US-4255335-A Preparation of 5-aroyl-1-loweralkylpyrrole-2-acetic acid derivatives MCNEILAB, INC. (US) 1981-03-10 US disclosed
US-4238396-A REACTING THE 5-CYANO DERIVATIVE WITH A GRIGNARD REAGENT FOLLOWED BY HYDROLYSIS TO OBTAIN THE 5-ACYL SAGAMI CHEMICAL RESEARCH CENTER (JP) 1980-12-09 US disclosed
US-3998844-A WITH AN AROYL CHLORIDE TO FORM A 5-AROYL-1-ALKYLPYRROLE-2-ACETIC ACID DERIVATIVE MCNEIL LABORATORIES, INCORPORATED (US) 1976-12-27 US disclosed