Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963930 | 0.93 | SIGMAR1 (0.53) | SIGMAR1KCNH2HTR7HTR1APTGS1 | |
| SCHEMBL7959679 | 0.89 | DRD3 (0.49) | SIGMAR1KCNH2HTR7HTR1A | |
| SCHEMBL7957403 | 0.85 | MAPT (0.46) | MAPTNPSR1SIGMAR1KCNH2HTR7 | |
| SCHEMBL7959137 | 0.84 | SIGMAR1 (0.53) | SIGMAR1KCNH2HTR7HTR1A | |
| Fumaric Acid SCHEMBL7959573 | 0.83 | SIGMAR1 (0.49) | SIGMAR1HTR7HTR1APTGS1PTGS2 | |
| Maleic Acid SCHEMBL7959572 | 0.83 | SIGMAR1 (0.49) | SIGMAR1HTR7HTR1APTGS1PTGS2 | |
| SCHEMBL15961278 | 0.76 | SIGMAR1 (0.79) | MAPTNPSR1SIGMAR1KCNH2HTR7 | |
| SCHEMBL7959536 | 0.76 | SIGMAR1 (0.52) | SIGMAR1HTR7HTR1A | |
| SCHEMBL7959986 | 0.76 | HTR1A (0.51) | SIGMAR1HTR1ASLC6A3 | |
| SCHEMBL7963946 | 0.74 | MAPT (0.46) | MAPTNPSR1SIGMAR1KCNH2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |