Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 4/20 | 0.44 |
| ▸ | NOS2 | P35228 | 3/20 | 0.44 |
| ▸ | NOS1 | P29475 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7452092 | 0.89 | ALDH1A1 (0.44) | NOS3NOS2ALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL29825088 | 0.89 | ALDH1A1 (0.44) | NOS3NOS2ALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL2572924 | 0.87 | NOS3 (0.41) | NOS3NOS2NOS1ALDH1A1SMN1; SMN2 | |
| SCHEMBL2570914 | 0.85 | NOS3 (0.40) | NOS3NOS2NOS1SMN1; SMN2HDAC8 | |
| SCHEMBL25211097 | 0.79 | SMN1; SMN2 (0.36) | NOS3NOS2NOS1SMN1; SMN2HDAC8 | |
| SCHEMBL10424020 | 0.79 | NISCH (0.42) | NOS3NOS2NOS1ALDH1A1SMN1; SMN2 | |
| SCHEMBL25196779 | 0.79 | ALDH1A1 (0.37) | NOS3NOS2NOS1ALDH1A1L3MBTL1 | |
| SCHEMBL29420719 | 0.74 | SMN1; SMN2 (0.50) | NOS3NOS2SMN1; SMN2ADRA2AADRA2B | |
| SCHEMBL218213 | 0.74 | SMN1; SMN2 (0.50) | NOS3NOS2SMN1; SMN2ADRA2AADRA2B | |
| SCHEMBL9319771 | 0.73 | CHRNB4 (0.44) | NOS3NOS2NOS1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |
| US-6207693-B1 | Benzamide derivatives having a vasopressin antagonistic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-03-27 | — | — | US | disclosed |