Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.58 |
| ▸ | RAB9A | P51151 | 5/20 | 0.58 |
| ▸ | HCRTR1 | O43613 | 8/20 | 0.51 |
| ▸ | HCRTR2 | O43614 | 8/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.44 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.44 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963947 | 0.83 | RAB9A (0.70) | SMN1; SMN2RAB9ANPC1ALDH1A1MAPK1 | |
| SCHEMBL7977556 | 0.81 | SMN1; SMN2 (0.58) | SMN1; SMN2RAB9ANPC1ALDH1A1MAPK1 | |
| SCHEMBL7964027 | 0.80 | POLB (0.71) | RAB9ANPC1ALDH1A1POLBCTDSP1 | |
| SCHEMBL7964168 | 0.79 | POLB (0.70) | RAB9ANPC1ALDH1A1POLBCTDSP1 | |
| SCHEMBL7977587 | 0.79 | NPC1 (0.58) | SMN1; SMN2RAB9AHCRTR1NPC1ALDH1A1 | |
| SCHEMBL7974288 | 0.79 | KMT2A (0.65) | SMN1; SMN2RAB9AHCRTR1NPC1ALDH1A1 | |
| SCHEMBL7974434 | 0.78 | POLB (0.65) | SMN1; SMN2RAB9ANPC1ALDH1A1POLB | |
| SCHEMBL7977631 | 0.77 | CYP1A2 (0.52) | SMN1; SMN2RAB9AHCRTR1HCRTR2NPC1 | |
| SCHEMBL7977633 | 0.76 | SMN1; SMN2 (0.56) | SMN1; SMN2RAB9ANPC1ALDH1A1POLB | |
| SCHEMBL7974500 | 0.75 | SMN1; SMN2 (0.60) | SMN1; SMN2RAB9ANPC1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | claimed |
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | disclosed |