Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 2/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974455 | 0.82 | TSHR (0.61) | CYP1A2CYP2D6TSHRCYP2C19NPSR1 | |
| SCHEMBL7977544 | 0.80 | LMNA (0.57) | CYP1A2CYP2D6TSHRCYP2C19RAB9A | |
| SCHEMBL7964027 | 0.80 | POLB (0.71) | POLBAPEX1CTDSP1TDP1L3MBTL1 | |
| SCHEMBL7974434 | 0.80 | POLB (0.65) | CYP1A2CYP2C19POLBAPEX1CTDSP1 | |
| SCHEMBL7980306 | 0.80 | NPSR1 (0.49) | CYP1A2CYP2D6TSHRCYP2C19POLB | |
| SCHEMBL7964168 | 0.80 | POLB (0.70) | POLBAPEX1CTDSP1TDP1L3MBTL1 | |
| SCHEMBL7980389 | 0.79 | NPC1 (0.49) | CYP1A2CYP2D6TSHRCYP2C19POLB | |
| SCHEMBL7977463 | 0.79 | HPGD (0.54) | TSHRPOLBAPEX1CTDSP1TDP1 | |
| SCHEMBL7974413 | 0.78 | SMN1; SMN2 (0.59) | CYP1A2CYP2C19POLBTDP1RAB9A | |
| SCHEMBL7977571 | 0.78 | NPC1 (0.53) | POLBRAB9ASMN1; SMN2NPC1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | claimed |
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | disclosed |