Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.66 |
| ▸ | NPC1 | O15118 | 7/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.55 |
| ▸ | RELA | Q04206 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ALPL | P05186 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.49 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980296 | 0.88 | SMN1; SMN2 (0.57) | RAB9ASMN1; SMN2NPC1HPGDNFKB1 | |
| SCHEMBL7964032 | 0.85 | NPC1 (0.60) | RAB9ASMN1; SMN2NPC1HPGDNFKB1 | |
| SCHEMBL7964004 | 0.84 | NPC1 (0.55) | RAB9ASMN1; SMN2NPC1HPGDNFKB1 | |
| SCHEMBL7964015 | 0.84 | EPHX2 (0.64) | RAB9ASMN1; SMN2NPC1HPGDNFKB1 | |
| SCHEMBL7977587 | 0.82 | NPC1 (0.58) | RAB9ASMN1; SMN2NPC1HPGDNFKB1 | |
| SCHEMBL7974288 | 0.82 | KMT2A (0.65) | RAB9ASMN1; SMN2NPC1HPGDNFKB1 | |
| SCHEMBL7974413 | 0.82 | SMN1; SMN2 (0.59) | RAB9ASMN1; SMN2NPC1HPGDNFKB1 | |
| SCHEMBL7745152 | 0.81 | RAB9A (1.00) | RAB9ASMN1; SMN2NPC1HPGDALDH1A1 | |
| SCHEMBL7964060 | 0.80 | SMN1; SMN2 (0.62) | RAB9ASMN1; SMN2NPC1HPGDNFKB1 | |
| SCHEMBL7977633 | 0.79 | SMN1; SMN2 (0.56) | RAB9ASMN1; SMN2NPC1HPGDNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | claimed |
| WO-2001034573-A1 | COMPOUNDS | ASTRAZENECA AB (SE) | 2001-05-17 | — | — | WO | disclosed |