Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.48 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.48 |
| ▸ | HCAR3 | P49019 | 5/20 | 0.46 |
| ▸ | P4HA1 | P13674 | 2/20 | 0.44 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.44 |
| ▸ | MIF | P14174 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.42 |
| ▸ | GABRP | O00591 | 1/20 | 0.42 |
| ▸ | GABRD | O14764 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.42 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.42 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4432631 | 0.77 | ALDH1A1 (0.65) | ALDH1A1CYP1A2CYP2C9HPGDCYP2C19 | |
| SCHEMBL15633263 | 0.77 | NPC1 (0.38) | CYP2C9TP53CXCR2KDM6BKDM4A | |
| SCHEMBL5445067 | 0.77 | ALDH1A1 (0.65) | ALDH1A1CYP1A2CYP2C9HPGDCYP2C19 | |
| SCHEMBL796408 | 0.74 | ALDH1A1 (0.61) | ALDH1A1CYP1A2CYP2C9HPGDCYP2C19 | |
| SCHEMBL13787819 | 0.74 | ALDH1A1 (0.61) | ALDH1A1CYP1A2CYP2C9HPGDCYP2C19 | |
| SCHEMBL29693605 | 0.74 | ALDH1A1 (1.00) | ALDH1A1CYP1A2CYP2C9HPGDCYP2C19 | |
| SCHEMBL3680735 | 0.74 | ALDH1A1 (0.77) | ALDH1A1CYP1A2CYP2C9HPGDCYP2C19 | |
| SCHEMBL147705 | 0.74 | ALDH1A1 (1.00) | ALDH1A1CYP1A2CYP2C9HPGDCYP2C19 | |
| SCHEMBL1928183 | 0.73 | CRBN (0.42) | ALDH1A1DDB1CRBNCXCR2L3MBTL1 | |
| SCHEMBL18275266 | 0.73 | METAP2 (0.38) | ALDH1A1CYP1A2CYP2C9CYP2C19CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616465-B1 | TRIAZINE-OXADIAZOLES | NOVARTIS AG (CH) | 2015-11-04 | — | — | EP | disclosed |
| US-20150025057-A1 | Triazine-oxadiazoles | NOVARTIS AG (CH) | 2015-01-22 | — | — | US | disclosed |
| US-8895733-B2 | Triazine-oxadiazoles | NOVARTIS AG (CH) | 2014-11-25 | — | — | US | disclosed |
| US-20140051676-A1 | Triazine-oxadiazoles | NOVARTIS AG (CH) | 2014-02-20 | — | — | US | disclosed |
| EP-2616465-A1 | TRIAZINE-OXADIAZOLES | Novartis AG (CH) | 2013-07-24 | — | — | EP | disclosed |
| WO-2012035023-A1 | TRIAZINE-OXADIAZOLES | NOVARTIS AG (CH) | 2012-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150025057-A1 | Triazine-oxadiazoles | OPRK1, OPRD1, OPRL1 | ALDH1A1 439/4885CYP1A2 32/4885CYP2C9 200/4885 |
| US-20140051676-A1 | Triazine-oxadiazoles | OPRK1, OPRD1, OPRL1 | ALDH1A1 439/4885CYP1A2 32/4885CYP2C9 200/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.