Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.46 |
| ▸ | CTSK | P43235 | 11/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 3/20 | 0.44 |
| ▸ | CTSB | P07858 | 3/20 | 0.44 |
| ▸ | CTSL | P07711 | 2/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.42 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.42 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5935027 | 0.88 | CASP1 (0.47) | TAS1R3TAS1R1CTSKCA1CTSS | |
| SCHEMBL7966128 | 0.84 | CTSK (0.52) | CTSKCA1CTSSCTSBCTSL | |
| SCHEMBL5934954 | 0.83 | MMP12 (0.49) | CTSKCA1CTSSCTSBCTSL | |
| SCHEMBL5935024 | 0.78 | CTSK (0.58) | CTSKCA1CTSSCTSBCTSL | |
| SCHEMBL5934909 | 0.73 | CASP1 (0.49) | CTSKCA1CTSSCTSBCTSL | |
| SCHEMBL6465007 | 0.72 | CTSL (0.58) | TAS1R3TAS1R1CTSKCTSSCTSB | |
| SCHEMBL18223966 | 0.71 | ALDH1A1 (0.56) | MMP2 | |
| SCHEMBL4669753 | 0.70 | CTSK (0.64) | CTSKCTSSCTSBCTSLCAPN1 | |
| SCHEMBL5934721 | 0.70 | CASP1 (0.58) | CTSKCA1CTSSCTSBCTSL | |
| SCHEMBL6943810 | 0.69 | CTSK (0.72) | CTSKCTSSCTSBCTSLCAPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331542-B1 | TREATING DISEASES CHARACTERIZED BY BONE LOSS OR EXCESSIVE CARTILAGE OR MATRIX DEGRADATION | SMITHKLINE BEECHAM CORPORATION | 2001-12-18 | — | — | US | disclosed |