Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | PTAFR | P25105 | 4/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7966316 | 1.00 | MEN1 (0.44) | MEN1KMT2APTAFRTHRBCYP3A4 | |
| SCHEMBL7966317 | 1.00 | MEN1 (0.44) | MEN1KMT2APTAFRTHRBCYP3A4 | |
| SCHEMBL7976695 | 0.82 | RAB9A (0.46) | MEN1KMT2ACCNCCDK8APP | |
| SCHEMBL7982797 | 0.79 | CYP1A2 (0.47) | PTAFRCYP3A4CYP1A2CLK1POLB | |
| SCHEMBL7982583 | 0.79 | CYP1A2 (0.47) | PTAFRCYP3A4CYP1A2CLK1POLB | |
| SCHEMBL7982584 | 0.76 | CCNC (0.40) | PTAFRCYP3A4CYP1A2CYP4F2CYP4A11 | |
| SCHEMBL7982586 | 0.76 | CCNC (0.40) | PTAFRCYP3A4CYP1A2CYP4F2CYP4A11 | |
| SCHEMBL7976964 | 0.74 | CACNA2D1 (0.41) | PTAFRPOLB | |
| SCHEMBL7966194 | 0.74 | CACNA2D1 (0.41) | PTAFRPOLB | |
| SCHEMBL7966272 | 0.74 | PTAFR (0.45) | PTAFRCYP4F2CYP4A11POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300352-B1 | FOR THERAPY OF ASTHMA | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | claimed |
| US-6300352-B1 | FOR THERAPY OF ASTHMA | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | disclosed |