Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 5/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA5A | P35218 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5845241 | 0.87 | LMNA (0.64) | LMNASMN1; SMN2CA2RAB9APOLB | |
| SCHEMBL567428 | 0.87 | LMNA (0.64) | LMNASMN1; SMN2CA2RAB9APOLB | |
| SCHEMBL440397 | 0.87 | LMNA (0.64) | LMNASMN1; SMN2CA2RAB9APOLB | |
| SCHEMBL17272346 | 0.85 | LMNA (0.45) | LMNASMN1; SMN2CA2RAB9APOLB | |
| SCHEMBL11246201 | 0.84 | CA2 (0.47) | LMNASMN1; SMN2CA2RAB9ACA1 | |
| SCHEMBL1545033 | 0.83 | CA2 (0.56) | LMNASMN1; SMN2CA2HTTPOLB | |
| SCHEMBL8425207 | 0.82 | LMNA (0.44) | LMNASMN1; SMN2CA2CA1CA9 | |
| SCHEMBL8424531 | 0.81 | CA2 (0.54) | LMNASMN1; SMN2CA2ALDH1A1TSHR | |
| SCHEMBL8649232 | 0.80 | LMNA (0.44) | LMNASMN1; SMN2POLBCA1CA9 | |
| SCHEMBL10334247 | 0.80 | LMNA (0.58) | LMNASMN1; SMN2CA2RAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6313160-B1 | FOR THERAPY AND PROPHYLAXIS OF MELATONINERGIC DISORDERS | ADIR ET COMPAGNIE (FR) | 2001-11-06 | — | — | US | disclosed |
| EP-0445026-B1 | Aminomethylpiperidine derivatives, their process for preparation and the pharmaceutical compositions containing them | ADIR (FR) | 1994-01-26 | — | — | EP | disclosed |
| US-5229399-A | Analgesics | ADIR ET COMPAGNIE (FR) | 1993-07-20 | — | — | US | disclosed |
| US-5229398-A | Analgesics | ADIR ET COMPAGNIE (FR) | 1993-07-20 | — | — | US | disclosed |
| US-5192775-A | Analgesics | ADIR ET COMPAGNIE (FR) | 1993-03-09 | — | — | US | disclosed |
| US-5112855-A | Nootropic Agents | CIBA-GEIGY CORPORATION (US) | 1992-05-12 | — | — | US | disclosed |
| EP-0445026-A1 | Aminomethylpiperidine derivatives, their process for preparation and the pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1991-09-04 | — | — | EP | disclosed |
| US-4957928-A | NOOTROPIC AGENTS, COGNITION ACTIVATORS | CIBA-GEIGY CORPORATION (US) | 1990-09-18 | — | — | US | disclosed |
| US-4329348-A | ANTIDEPRESSANTS AND PSYCHOSTIMULANTS | CIBA-GEIGY CORPORATION (US) | 1982-05-11 | — | — | US | disclosed |
| US-4140781-A | Analgesic and neuraleptic 2-piperidinoalkyl-1,4-benzodioxans | CIBA-GEIGY CORPORATION (US) | 1979-02-20 | — | — | US | disclosed |
| US-4129655-A | Neuroleptic 2-piperidinoalkyl-1,4-benzodioxans | CIBA-GEIGY CORPORATION (US) | 1978-12-12 | — | — | US | disclosed |
| US-4104396-A | NEUROLEPTIC, ANALGESIC | CIBA-GEIGY CORPORATION (US) | 1978-08-01 | — | — | US | disclosed |
| US-4039676-A | NEUROLEPTIC AGENTS | CIBA-GEIGY CORPORATION (US) | 1977-08-02 | — | — | US | disclosed |