Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | PPARD | Q03181 | 2/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.36 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7966432 | 0.80 | LMNA (0.61) | LMNASMN1; SMN2POLBCA1CA9 | |
| SCHEMBL8787797 | 0.79 | LMNA (0.43) | LMNASMN1; SMN2HTR2CKCNH2FFAR1 | |
| SCHEMBL9690306 | 0.78 | LMNA (0.42) | LMNASMN1; SMN2POLB | |
| SCHEMBL8344592 | 0.76 | ALDH1A1 (0.46) | LMNAHTR6BDKRB1 | |
| SCHEMBL8647038 | 0.75 | HTR6 (0.36) | LMNASMN1; SMN2FFAR4HTR6CA12 | |
| SCHEMBL6004127 | 0.75 | VDR (0.46) | LMNAFFAR4POLBHTR6CA12 | |
| SCHEMBL2098311 | 0.74 | KMT2A (0.49) | LMNASMN1; SMN2CA12CA1CA9 | |
| SCHEMBL4065055 | 0.74 | KMT2A (0.49) | LMNASMN1; SMN2CA12CA1CA9 | |
| SCHEMBL6221876 | 0.74 | KMT2A (0.49) | LMNASMN1; SMN2CA12CA1CA9 | |
| SCHEMBL1866143 | 0.73 | CA12 (0.42) | CA12CA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5763444-A | CENTRAL NERVOUS SYSTEM AGENTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-06-09 | — | — | US | disclosed |
| EP-0761666-A2 | Antidepressant 1-arylalkyl-4-(alkoxypyridinyl)- or 4-(alkoxypyrimidinyl)piperazine derivatives | BRISTOL-MYERS SQUIBB COMPANY (US) | 1997-03-12 | — | — | EP | disclosed |