Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ECE1 | P42892 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 2/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | PTAFR | P25105 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | GLS | O94925 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7966497 | 1.00 | SIGMAR1 (0.44) | SIGMAR1LMNAECE1ALDH1A1MEN1 | |
| SCHEMBL8022664 | 0.92 | C3AR1 (0.45) | SIGMAR1C3AR1 | |
| SCHEMBL7978383 | 0.89 | LMNA (0.46) | LMNAECE1ALDH1A1ACACBPOLB | |
| SCHEMBL7976785 | 0.89 | ECE1 (0.48) | LMNAECE1ALDH1A1ACACBPOLB | |
| SCHEMBL7976781 | 0.89 | ECE1 (0.48) | LMNAECE1ALDH1A1ACACBPOLB | |
| SCHEMBL7978380 | 0.89 | LMNA (0.46) | LMNAECE1ALDH1A1ACACBPOLB | |
| SCHEMBL7979904 | 0.85 | NAPRT (0.48) | LMNAECE1POLBHPGDHTT | |
| SCHEMBL7979905 | 0.85 | NAPRT (0.48) | LMNAECE1POLBHPGDHTT | |
| SCHEMBL7979963 | 0.81 | PTAFR (0.47) | LMNAECE1EPHX2POLBHPGD | |
| SCHEMBL7982544 | 0.81 | ALDH1A1 (0.43) | ALDH1A1MEN1KMT2APOLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300352-B1 | FOR THERAPY OF ASTHMA | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | claimed |
| US-6300352-B1 | FOR THERAPY OF ASTHMA | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | disclosed |