Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 1/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | PTAFR | P25105 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 3/20 | 0.40 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PTGIR | P43119 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 2/20 | 0.38 |
| ▸ | ACACA | Q13085 | 2/20 | 0.38 |
| ▸ | EIF2S1 | P05198 | 1/20 | 0.38 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7978375 | 1.00 | PDK1 (0.50) | PDK1CYP11B1CYP11B2PTAFRHTT | |
| SCHEMBL7966644 | 0.90 | CYP11B1 (0.45) | PDK1CYP11B1CYP11B2PTAFRHTT | |
| SCHEMBL7966646 | 0.90 | CYP11B1 (0.45) | PDK1CYP11B1CYP11B2PTAFRHTT | |
| SCHEMBL7966313 | 0.85 | PTAFR (0.45) | PTAFRSLC2A1POLBHPGD | |
| SCHEMBL7966315 | 0.85 | PTAFR (0.45) | PTAFRSLC2A1POLBHPGD | |
| SCHEMBL7978652 | 0.81 | CYP11B2 (0.43) | CYP11B1CYP11B2PTAFRSLC2A1 | |
| SCHEMBL7978653 | 0.81 | CYP11B2 (0.43) | CYP11B1CYP11B2PTAFRSLC2A1 | |
| SCHEMBL8022091 | 0.81 | NAMPT (0.46) | PTAFRHTTNAMPTKMT2APOLB | |
| SCHEMBL7976682 | 0.81 | NAMPT (0.46) | PTAFRHTTNAMPTKMT2APOLB | |
| SCHEMBL7976678 | 0.81 | NAMPT (0.46) | PTAFRHTTNAMPTKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6300352-B1 | FOR THERAPY OF ASTHMA | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | claimed |
| EP-0971892-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Astra Pharmaceuticals Limited (GB) | 2000-01-19 | — | — | EP | claimed |
| WO-1998042670-A1 | NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ASTRA PHARMACEUTICALS LTD. (GB) | 1998-10-01 | — | — | WO | claimed |
| US-6300352-B1 | FOR THERAPY OF ASTHMA | ASTRAZENECA AB (SE) | 2001-10-09 | — | — | US | disclosed |