Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | CTSS | P25774 | 2/20 | 0.45 |
| ▸ | CTSK | P43235 | 2/20 | 0.45 |
| ▸ | AKT1 | P31749 | 2/20 | 0.45 |
| ▸ | GPR52 | Q9Y2T5 | 7/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8837533 | 0.85 | CA12 (0.49) | CA12CA1CA7CA14SIGMAR1 | |
| SCHEMBL9608852 | 0.80 | SIGMAR1 (0.46) | CA12CA1CA7CA14SIGMAR1 | |
| SCHEMBL6824553 | 0.78 | GPR52 (0.55) | GPR52 | |
| SCHEMBL6824556 | 0.78 | GPR52 (0.55) | GPR52 | |
| SCHEMBL7789634 | 0.77 | CTSK (0.55) | CTSKGPR52 | |
| SCHEMBL7789631 | 0.77 | CTSK (0.55) | CTSKGPR52 | |
| SCHEMBL16278567 | 0.77 | PPARA (0.55) | CTSSCTSKCTSLCTSBATM | |
| SCHEMBL20144659 | 0.77 | PPARA (0.55) | CTSSCTSKCTSLCTSBATM | |
| SCHEMBL16278565 | 0.77 | PPARA (0.55) | CTSSCTSKCTSLCTSBATM | |
| SCHEMBL16278568 | 0.77 | PPARA (0.55) | CTSSCTSKCTSLCTSBATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6270957-B1 | USEFUL IN THE TREATMENT AND PREVENTION OF HIV (HUMAN IMMUNODEFICIENCY VIRUS)-MEDIATED DISORDERS, INCLUDING AIDS (ACQUIRE IMMUNODEFICIENCY SYNDROME) | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2001-08-07 | — | — | US | disclosed |
| WO-1999010373-A1 | NON-IMMUNOSUPPRESSIVE CYCLOSPORINS AND THEIR USE IN THE PREVENTION AND TREATMENT OF HIV INFECTION | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1999-03-04 | — | — | WO | disclosed |