Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | SRC | P12931 | 2/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 5/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.31 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.31 |
| ▸ | GPR6 | P46095 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.30 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.30 |
| ▸ | FYN | P06241 | 1/20 | 0.30 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7599997 | 0.93 | JAK2 (0.34) | JAK2ABL1SRCRXFP1ADRA1D | |
| Hydrochloric Acid SCHEMBL7485053 | 0.90 | PTGES (0.33) | JAK2MAP3K7GPR6LCK | |
| SCHEMBL7963910 | 0.90 | PTK2 (0.33) | JAK2MAP3K7GPR6LCK | |
| SCHEMBL7965063 | 0.90 | PTGES (0.34) | ADRA1DADRA1AADRA1BMAP3K7 | |
| SCHEMBL7964770 | 0.90 | MAP3K7 (0.33) | JAK2ADRA1DADRA1AADRA1BMAP3K7 | |
| SCHEMBL7478975 | 0.90 | MAP3K7 (0.31) | MAP3K7GPR6 | |
| Hydrochloric Acid SCHEMBL7970313 | 0.90 | PTK2 (0.33) | MAP3K7GPR6 | |
| SCHEMBL7966512 | 0.90 | BTK (0.34) | JAK2MAP3K7LCKABCB1ABCG2 | |
| SCHEMBL7482003 | 0.90 | MAP3K7 (0.33) | JAK2MAP3K7LCKABCB1ABCG2 | |
| SCHEMBL7967130 | 0.89 | CACNA1G (0.33) | MAP3K7ABCB1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6316482-B1 | FOR THERAPY AND PROPHYLAXIS OF HYPERTENSION, HEART FAILURE, RENAL INSUFFICIENCY, EDEMA, ASCITES, VASOPRESSIN PARASECRETION SYNDROME, HEPATOCIRRHOSIS, HYPONATREMIA, HYPOKALEMIA, DIABETIC, CIRCULATION DISORDER, CEREBROVASCULAR DISEASE | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-11-13 | — | — | US | disclosed |