SCHEMBL7967434

SCHEMBL7967434

Cn1c(C(F)(F)F)cc(=O)n(-c2c(F)cc3c(c2NC(=O)C=Cc2ccccc2)NC(=O)CO3)c1=O

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.39
RAB9A P51151 3/20 0.39
LMNA P02545 2/20 0.39
KMT2A Q03164 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
HTT P42858 1/20 0.39
TRPV1 Q8NER1 3/20 0.39
EGFR P00533 4/20 0.34
MAPT P10636 3/20 0.34
KDM4E B2RXH2 1/20 0.34
MEN1 O00255 1/20 0.34
NPC1 O15118 1/20 0.34
POLB P06746 1/20 0.34
MMP1 P03956 2/20 0.33
MMP2 P08253 2/20 0.33
MMP9 P14780 2/20 0.33
PADI4 Q9UM07 1/20 0.33
MAOB P27338 1/20 0.33
IMPDH2 P12268 1/20 0.32
MAOA P21397 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6849141 0.76
SCHEMBL7563867 0.67 NR3C2 (0.39) MAPTPOLB
SCHEMBL7977920 0.63 NR3C2 (0.45)
SCHEMBL6789396 0.61 DHFR (0.33)
SCHEMBL9430091 0.60 GPR35 (0.30)
SCHEMBL21593638 0.58 MMP1 (0.71) ALDH1A1EGFRMMP1MMP2MMP9
SCHEMBL9220684 0.58 RIPK1 (0.32)
SCHEMBL9429913 0.58
SCHEMBL9429794 0.58 GPR35 (0.32)
SCHEMBL14360567 0.58 MYC (0.54) ALDH1A1KDM4EPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6294503-B1 HERBICIDAL COMPOSITIONS CONTAINING HETEROCYCLES ISHIHARA SANGYO KAISHA, LTD. (JP) 2001-09-25 US claimed
US-6294503-B1 HERBICIDAL COMPOSITIONS CONTAINING HETEROCYCLES ISHIHARA SANGYO KAISHA, LTD. (JP) 2001-09-25 US disclosed