Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.65 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.65 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.59 |
| ▸ | HTR7 | P34969 | 2/20 | 0.55 |
| ▸ | DRD2 | P14416 | 2/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | DRD1 | P21728 | 1/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.52 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7955357 | 0.98 | HRH3 (0.63) | HRH3SLC6A3SIGMAR1HTR7DRD2 | |
| SCHEMBL872805 | 0.88 | HTR7 (0.66) | HRH3SLC6A3SIGMAR1HTR7DRD2 | |
| SCHEMBL6310987 | 0.81 | PRMT6 (0.62) | HRH3DRD2 | |
| SCHEMBL1801087 | 0.81 | HRH3 (0.63) | HRH3SLC6A3SIGMAR1DRD2SLC6A4 | |
| SCHEMBL29966226 | 0.80 | ALDH1A1 (0.64) | HRH3DRD2 | |
| SCHEMBL10370403 | 0.80 | ALDH1A1 (0.64) | HRH3DRD2 | |
| SCHEMBL3154468 | 0.80 | ALDH1A1 (0.64) | HRH3DRD2 | |
| SCHEMBL10367496 | 0.80 | ALDH1A1 (0.64) | HRH3DRD2 | |
| SCHEMBL5175647 | 0.80 | LTA4H (0.60) | HRH3 | |
| SCHEMBL11274717 | 0.79 | HRH3 (0.71) | HRH3SLC6A3SIGMAR1SLC6A4L3MBTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6214832-B1 | BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC. | 2001-04-10 | — | — | US | disclosed |
| US-4767769-A | HISTAMINE-H2 ANTAGONISTS | THE BOOTS COMPANY PLC (GB) | 1988-08-30 | — | — | US | disclosed |
| EP-0172631-A1 | Therapeutic agents | The Boots Company PLC (GB) | 1986-02-26 | — | — | EP | disclosed |