Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 2/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | BCL9 | O00512 | 1/20 | 0.34 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7532281 | 0.83 | ALDH1A1 (0.45) | MEN1KMT2AGAAALDH1A1MAPT | |
| SCHEMBL6199441 | 0.77 | MEN1 (0.44) | MEN1KMT2AGAAALDH1A1MAPT | |
| SCHEMBL4294571 | 0.74 | MGLL (0.42) | PKMMEN1KMT2AGAAMAPT | |
| SCHEMBL3988068 | 0.74 | MGLL (0.41) | MEN1KMT2AALDH1A1MAPTHTT | |
| SCHEMBL14760554 | 0.73 | ALDH1A1 (0.43) | MEN1KMT2AGAAALDH1A1MAPT | |
| SCHEMBL6197215 | 0.71 | ADRA1A (0.36) | MEN1KMT2AMGLLBCL9CTNNB1 | |
| SCHEMBL8337661 | 0.71 | ADRA1A (0.36) | MEN1KMT2AMGLLBCL9CTNNB1 | |
| SCHEMBL6194063 | 0.70 | CACNA1F (0.41) | MEN1KMT2A | |
| SCHEMBL6644031 | 0.69 | MYLK (0.39) | PKMMEN1KMT2AGAAALDH1A1 | |
| SCHEMBL6715274 | 0.69 | BCL9 (0.35) | PKMALDH1A1MAPTFAAHMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6268369-B1 | ALPHA SUB 1 INHIBITORS | SYNAPTIC PHARMACEUTICAL CORPORATION | 2001-07-31 | — | — | US | disclosed |
| EP-0790826-A4 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMA CORP (US) | 1998-11-11 | — | — | EP | disclosed |
| EP-0790826-A1 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-08-27 | — | — | EP | disclosed |