Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 7/20 | 0.42 |
| ▸ | BACE1 | P56817 | 3/20 | 0.39 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | WRN | Q14191 | 1/20 | 0.36 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7966664 | 0.84 | HCAR2 (0.46) | HCAR3HCAR2ARHSD11B1ALDH1A1 | |
| SCHEMBL7956282 | 0.84 | HCAR2 (0.46) | HCAR3HCAR2ARHSD11B1ALDH1A1 | |
| SCHEMBL7030070 | 0.84 | HCAR2 (0.46) | HCAR3HCAR2ARHSD11B1ALDH1A1 | |
| SCHEMBL7984718 | 0.83 | CHRNA1 (0.42) | HCAR3HCAR2KDM4EALDH1A1CYP1A2 | |
| SCHEMBL6026628 | 0.82 | MEN1 (0.37) | HCAR3HCAR2ARHSD11B1NOTUM | |
| SCHEMBL7593441 | 0.81 | ALDH1A1 (0.38) | HCAR3HCAR2HSD11B1NOTUMKDM4E | |
| SCHEMBL7965515 | 0.81 | PTGS2 (0.37) | HCAR3HCAR2HSD11B1KDM4EALDH1A1 | |
| SCHEMBL7967039 | 0.81 | PTGS2 (0.37) | HCAR3HCAR2HSD11B1KDM4EALDH1A1 | |
| SCHEMBL7972602 | 0.80 | KIF11 (0.39) | KIF11BACE1ARNOTUMKDM4E | |
| SCHEMBL7968717 | 0.79 | KIF11 (0.46) | KIF11BACE1ARHSD11B1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265436-B1 | ANTIINFLAMMATORY AGENTS | OXIS THERAPEUTICS INC. | 2001-07-24 | — | — | US | disclosed |