Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 11/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7953962 | 0.88 | ABCB1 (0.54) | ABCB1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL7969773 | 0.86 | ABCB1 (0.47) | ABCB1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL7966028 | 0.85 | ABCB1 (0.54) | ABCB1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL7965198 | 0.85 | PRMT5 (0.45) | ABCB1MEN1KMT2ASMN1; SMN2PRMT5 | |
| SCHEMBL7968938 | 0.84 | OPRL1 (0.38) | ABCB1MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL7969553 | 0.83 | L3MBTL1 (0.55) | ABCB1MEN1KMT2ASMN1; SMN2PRMT5 | |
| SCHEMBL7968932 | 0.83 | OPRM1 (0.35) | ABCB1HTR1ADRD2HTR2ADRD3 | |
| SCHEMBL7953297 | 0.83 | LMNA (0.55) | ABCB1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL7953344 | 0.82 | KDM4E (0.53) | ABCB1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL7966950 | 0.82 | TSHR (0.56) | ABCB1MEN1KMT2ASMN1; SMN2PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |
| EP-0976747-A2 | Use of 5HT-1F receptor antagonists for treating anxiety disorders | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |