Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 2/20 | 0.38 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.38 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.36 |
| ▸ | MAP1LC3A | Q9H492 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7981120 | 0.90 | KDR (0.47) | MCL1ACMSDFLT1FLT4KDR | |
| SCHEMBL7746568 | 0.90 | KDR (0.41) | FLT1FLT4KDRHDAC6MAPT | |
| SCHEMBL7986526 | 0.87 | KDR (0.42) | FLT1FLT4KDRHDAC6MAPT | |
| SCHEMBL7969457 | 0.87 | KDR (0.42) | FLT1FLT4KDRSERPINE1MAPT | |
| SCHEMBL7986013 | 0.87 | KDR (0.39) | FLT1FLT4KDRMAPTALDH1A1 | |
| SCHEMBL7980106 | 0.85 | KDR (0.42) | FLT1FLT4KDRMAPTTP53 | |
| SCHEMBL7739003 | 0.84 | HPN (0.44) | FLT1FLT4KDRMAPTALDH1A1 | |
| SCHEMBL7744769 | 0.81 | KDR (0.53) | FLT1FLT4KDRALDH1A1ALOX15 | |
| SCHEMBL7969519 | 0.78 | KDR (0.44) | MCL1ACMSDFLT1FLT4KDR | |
| SCHEMBL7982846 | 0.76 | KDR (0.49) | FLT1FLT4KDRALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228871-B1 | THIAZOLE OR OXAZOLE DERIVATIVE TYROSINE KINASE INHIBITORS; ANTICARCINOGENIC AGENTS; AUTOIMMUNE DISEASES; DIABETIC RETINOPATHY | MERCK & CO., INC. | 2001-05-08 | — | — | US | claimed |