Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 2/20 | 0.51 |
| ▸ | PDE2A | O00408 | 3/20 | 0.49 |
| ▸ | MAP3K8 | P41279 | 4/20 | 0.46 |
| ▸ | SRC | P12931 | 3/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | PRKCG | P05129 | 1/20 | 0.42 |
| ▸ | PRKCB | P05771 | 1/20 | 0.42 |
| ▸ | PRKCA | P17252 | 1/20 | 0.42 |
| ▸ | PRKCH | P24723 | 1/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.42 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.42 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.42 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.42 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7980015 | 0.95 | LCK (0.52) | LCKPDE2AMAP3K8SRCL3MBTL1 | |
| SCHEMBL7983648 | 0.93 | LCK (0.57) | LCKPDE2AMAP3K8SRCDHFR | |
| SCHEMBL7983209 | 0.88 | LCK (0.58) | LCKPDE2ASRCL3MBTL1FGFR1 | |
| SCHEMBL7983672 | 0.86 | FGFR1 (0.53) | LCKMAP3K8SRCFGFR1EGFR | |
| SCHEMBL7969613 | 0.82 | PDE2A (0.38) | LCKPDE2ALMNAMAPK1 | |
| SCHEMBL7979828 | 0.82 | LCK (0.48) | LCKPDE2AFGFR1 | |
| SCHEMBL7970503 | 0.82 | CAMK2D (0.43) | LCKPDE2A | |
| SCHEMBL7987029 | 0.81 | LCK (0.45) | LCKPDE2AFGFR1 | |
| SCHEMBL7969691 | 0.81 | NPC1 (0.39) | LCKPDE2AADORA2AADORA1CCNT1 | |
| SCHEMBL7983671 | 0.81 | MAP3K8 (0.46) | PDE2AMAP3K8LMNAMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | claimed |
| WO-1999009845-A1 | IMIDAZOQUINOXALINE PROTEIN TYROSINE KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-03-04 | — | — | WO | claimed |
| US-6235740-B1 | AUTOIMMUNE DISEASES; ANTIPROLIFERATION AGENTS | BRISTOL-MYERS SQUIBB CO. | 2001-05-22 | — | — | US | disclosed |