Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 3/20 | 0.67 |
| ▸ | MMP13 | P45452 | 3/20 | 0.67 |
| ▸ | ESRRA | P11474 | 1/20 | 0.60 |
| ▸ | GSK3B | P49841 | 2/20 | 0.57 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.56 |
| ▸ | CLK1 | P49759 | 1/20 | 0.56 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.56 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.56 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.56 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.56 |
| ▸ | NAT1 | P18440 | 3/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.55 |
| ▸ | MGAM | O43451 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | SI | P14410 | 1/20 | 0.55 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.55 |
| ▸ | CRHBP | P24387 | 1/20 | 0.54 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.54 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7969788 | 1.00 | MMP3 (0.67) | MMP3MMP13ESRRAGSK3BCSNK2A2 | |
| SCHEMBL18103063 | 0.81 | MMP3 (0.73) | MMP3MMP13GSK3BCSNK2A2CLK1 | |
| SCHEMBL8177661 | 0.81 | MMP3 (1.00) | MMP3MMP13CSNK2A2CLK1CSNK2B | |
| SCHEMBL8177658 | 0.81 | MMP3 (1.00) | MMP3MMP13CSNK2A2CLK1CSNK2B | |
| SCHEMBL18103088 | 0.81 | MMP3 (1.00) | MMP3MMP13CSNK2A2CLK1CSNK2B | |
| SCHEMBL4053689 | 0.79 | CRHBP (0.58) | MMP3MMP13GSK3BCSNK2A2CLK1 | |
| SCHEMBL4053687 | 0.79 | CRHBP (0.58) | MMP3MMP13GSK3BCSNK2A2CLK1 | |
| SCHEMBL4553082 | 0.79 | MMP3 (0.68) | MMP3MMP13CSNK2A2CLK1CSNK2B | |
| SCHEMBL4553083 | 0.79 | MMP3 (0.68) | MMP3MMP13CSNK2A2CLK1CSNK2B | |
| SCHEMBL8310830 | 0.77 | TDP2 (0.75) | MMP3MMP13GSK3BNAT1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251928-B1 | ADMINISTERING BENZYLIDENE RHODANINES WHICH ARE USEFUL AS AGENTS IN TREATING OR PREVENTING CONDITIONS ASSOCIATED WITH BETA-AMYLOID PEPTIDE IN A MAMMAL | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| EP-0677517-A1 | Treatment of Alzheimer's disease employing inhibitors of cathepsin D | ELI LILLY AND COMPANY (US) | 1995-10-18 | — | — | EP | disclosed |