Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | TNFRSF1A | P19438 | 2/20 | 0.46 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.45 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27610920 | 0.79 | ALDH1A1 (0.58) | RAB9ATUBB1NPC1TDP1ALDH1A1 | |
| SCHEMBL8558338 | 0.78 | DHFR (0.40) | TUBB1TDP1TNFRSF1AALDH1A1TUBB4A | |
| SCHEMBL864643 | 0.76 | RAB9A (0.69) | RAB9ANPC1TDP1ALDH1A1CYP2A6 | |
| SCHEMBL9129690 | 0.76 | RAB9A (0.69) | RAB9ANPC1TDP1ALDH1A1CYP2A6 | |
| SCHEMBL7958272 | 0.75 | MMP13 (0.64) | HPGDMEN1KMT2A | |
| SCHEMBL7958269 | 0.75 | MMP13 (0.64) | HPGDMEN1KMT2A | |
| SCHEMBL5365834 | 0.75 | TNFRSF1A (0.46) | TDP1TNFRSF1AALDH1A1CYP2A6HPGD | |
| SCHEMBL3997051 | 0.75 | APP (0.64) | RAB9ANPC1TDP1ALDH1A1MAPT | |
| SCHEMBL348599 | 0.74 | RAB9A (0.58) | RAB9ANPC1TDP1ALDH1A1CYP2A6 | |
| SCHEMBL23223734 | 0.73 | RAB9A (0.69) | RAB9ANPC1TDP1ALDH1A1CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6251928-B1 | ADMINISTERING BENZYLIDENE RHODANINES WHICH ARE USEFUL AS AGENTS IN TREATING OR PREVENTING CONDITIONS ASSOCIATED WITH BETA-AMYLOID PEPTIDE IN A MAMMAL | ELI LILLY AND COMPANY | 2001-06-26 | — | — | US | disclosed |
| EP-0677517-A1 | Treatment of Alzheimer's disease employing inhibitors of cathepsin D | ELI LILLY AND COMPANY (US) | 1995-10-18 | — | — | EP | disclosed |