SCHEMBL7970248

SCHEMBL7970248

COc1ccc(CN2Cc3cc(C(=O)NC(C)C)c(F)cc3C2=O)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDH1 O75874 1/20 0.42
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
HDAC6 Q9UBN7 4/20 0.41
ALDH1A1 P00352 6/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
KDM4E B2RXH2 2/20 0.41
HPGD P15428 2/20 0.41
CYP3A4 P08684 1/20 0.40
DPP4 P27487 1/20 0.40
HDAC1 Q13547 5/20 0.40
NPC1 O15118 1/20 0.40
LMNA P02545 1/20 0.40
RAB9A P51151 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2C19 P33261 1/20 0.40
HDAC3 O15379 1/20 0.40
HDAC4 P56524 1/20 0.40
HDAC7 Q8WUI4 1/20 0.40
HDAC2 Q92769 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7979545 0.90 BRD4 (0.45) IDH1MEN1KMT2AHDAC6ALDH1A1
SCHEMBL7983775 0.88 MEN1 (0.45) IDH1MEN1KMT2AHDAC6ALDH1A1
SCHEMBL7985081 0.88 ALDH1A1 (0.47) IDH1MEN1KMT2AHDAC6ALDH1A1
SCHEMBL7982080 0.86 CHRM1 (0.47) IDH1MEN1KMT2AHDAC6ALDH1A1
SCHEMBL7983778 0.86 CNR1 (0.49) ALDH1A1CNR1CNR2FAAHABHD6
SCHEMBL7981151 0.82 CACNA1G (0.48) IDH1MEN1KMT2AHDAC6ALDH1A1
SCHEMBL7983771 0.81 IDH1 (0.48) IDH1MEN1KMT2AHDAC6ALDH1A1
SCHEMBL30059330 0.80 PARK7 (0.46) IDH1MEN1KMT2AHDAC6HDAC1
SCHEMBL14991601 0.75 LMNA (0.49) MEN1KMT2ALMNAHTT
SCHEMBL18863244 0.75 ADAM17 (0.51) MEN1KMT2ALMNAHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010001946-A1 TRIAZOLE DERIVATIVE OR SALT THEREOF アステラス製薬株式会社 (JP) 2010-01-07 WO disclosed