Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 6/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
| ▸ | HNF4A | P41235 | 1/20 | 0.31 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5736694 | 0.86 | RARB (0.41) | SLC6A2SLC6A4 | |
| SCHEMBL7980972 | 0.86 | SLC6A2 (0.33) | SLC6A2SLC6A4NOS3NOS1NOS2 | |
| SCHEMBL5735318 | 0.82 | FFAR1 (0.44) | SLC6A2SLC6A4DPP4DPP8DPP9 | |
| SCHEMBL7711974 | 0.81 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3FFAR1 | |
| SCHEMBL5737092 | 0.79 | MMP13 (0.42) | TP53DRD2DRD3 | |
| SCHEMBL7984235 | 0.78 | HNF4A (0.38) | HNF4AFFAR1FFAR4 | |
| SCHEMBL7987639 | 0.77 | HNF4A (0.37) | HNF4AFFAR1FFAR4 | |
| SCHEMBL5736007 | 0.72 | RARB (0.39) | SLC6A2SLC6A4 | |
| SCHEMBL10412862 | 0.70 | GABRP (0.41) | HNF4AFFAR1KDM4EALDH1A1 | |
| SCHEMBL7984143 | 0.70 | TBXAS1 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303785-B1 | SUBSTITUTED N-CYCLOPROPYLTETRAHYDROISOQUINOLINES | ALLERGAN SALES, INC. | 2001-10-16 | — | — | US | disclosed |