Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HNF4A | P41235 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 10/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.35 |
| ▸ | GABRD | O14764 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.35 |
| ▸ | GABRE | P78334 | 1/20 | 0.35 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7987639 | 0.87 | HNF4A (0.37) | HNF4AFFAR1FFAR4GABRPGABRD | |
| SCHEMBL10412862 | 0.80 | GABRP (0.41) | HNF4AFFAR1GABRPGABRDGABRA1 | |
| SCHEMBL7970475 | 0.78 | SLC6A2 (0.37) | HNF4AFFAR1FFAR4 | |
| SCHEMBL7984143 | 0.77 | TBXAS1 (0.50) | — | |
| SCHEMBL394617 | 0.73 | XDH (0.46) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL6132151 | 0.73 | GABRP (0.41) | HNF4AFFAR1GABRPGABRDGABRA1 | |
| SCHEMBL5735645 | 0.73 | CA12 (0.47) | CYP2C9 | |
| SCHEMBL8773234 | 0.73 | CYP1A1 (0.41) | FFAR1FFAR4 | |
| SCHEMBL4549023 | 0.71 | ACE2 (0.53) | ACE2RARB | |
| SCHEMBL23480907 | 0.70 | SLC22A12 (0.46) | FFAR1KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6303785-B1 | SUBSTITUTED N-CYCLOPROPYLTETRAHYDROISOQUINOLINES | ALLERGAN SALES, INC. | 2001-10-16 | — | — | US | disclosed |