Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | PLAU | P00749 | 3/20 | 0.48 |
| ▸ | PLG | P00747 | 2/20 | 0.48 |
| ▸ | PLAT | P00750 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | STAT1 | P42224 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7973003 | 0.86 | MEN1 (0.48) | CNR1TP53RAB9ANPC1MAPT | |
| SCHEMBL7964851 | 0.85 | CNR1 (0.55) | CNR1TP53RAB9ANPC1MAPT | |
| SCHEMBL7957755 | 0.85 | CNR1 (0.55) | CNR1TP53SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7969315 | 0.84 | CA2 (0.54) | CNR1TP53TSHRPLAUPLG | |
| SCHEMBL7969904 | 0.83 | MAPT (0.41) | CNR1TP53RAB9ANPC1MAPT | |
| SCHEMBL7969314 | 0.83 | KMT2A (0.56) | TP53TSHRRAB9ANPC1MAPT | |
| SCHEMBL7955623 | 0.83 | NPC1 (0.50) | TP53TSHRPLAURAB9ANPC1 | |
| SCHEMBL7957018 | 0.82 | CSF1R (0.52) | CNR1TP53RAB9ANPC1MAPT | |
| SCHEMBL7959068 | 0.82 | NR1H4 (0.44) | TP53TSHRPLAURAB9ANPC1 | |
| SCHEMBL7975294 | 0.82 | HTR1A (0.45) | CNR1TP53RAB9ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | disclosed |