Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7955623 | 0.92 | NPC1 (0.50) | NR1H4MAPTSMN1; SMN2LMNANPC1 | |
| SCHEMBL7969315 | 0.85 | CA2 (0.54) | MAPTSMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL7969958 | 0.83 | MEN1 (0.48) | MAPTSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL7969314 | 0.82 | KMT2A (0.56) | MAPTSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL7970519 | 0.82 | CNR1 (0.57) | MAPTSMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL7957018 | 0.81 | CSF1R (0.52) | MAPTSMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL7968563 | 0.81 | RAB9A (0.55) | MAPTSMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL7959052 | 0.80 | HPSE (0.42) | MAPTSMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL7966117 | 0.80 | RAF1 (0.48) | NR1H4MAPTSMN1; SMN2LMNANPC1 | |
| SCHEMBL7973003 | 0.79 | MEN1 (0.48) | MAPTSMN1; SMN2LMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | disclosed |