Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | CNR1 | P21554 | 7/20 | 0.45 |
| ▸ | TEK | Q02763 | 2/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.42 |
| ▸ | CDK8 | P49336 | 2/20 | 0.42 |
| ▸ | PRKX | P51817 | 2/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.42 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7968563 | 0.94 | RAB9A (0.55) | MEN1RAB9AKMT2ANPC1MAPT | |
| SCHEMBL7964851 | 0.93 | CNR1 (0.55) | MEN1RAB9AKMT2ANPC1MAPT | |
| SCHEMBL7957755 | 0.87 | CNR1 (0.55) | MEN1KMT2ACNR1CSF1RFLT1 | |
| SCHEMBL7970519 | 0.86 | CNR1 (0.57) | MEN1RAB9AKMT2ANPC1MAPT | |
| SCHEMBL7969314 | 0.85 | KMT2A (0.56) | MEN1RAB9AKMT2ANPC1MAPT | |
| SCHEMBL7957018 | 0.84 | CSF1R (0.52) | MEN1RAB9AKMT2ANPC1MAPT | |
| SCHEMBL7975298 | 0.83 | MAPT (0.55) | MEN1RAB9AKMT2AMAPTTEK | |
| SCHEMBL7969904 | 0.83 | MAPT (0.41) | MEN1RAB9AKMT2ANPC1MAPT | |
| SCHEMBL7975294 | 0.83 | HTR1A (0.45) | MEN1RAB9AKMT2ANPC1MAPT | |
| SCHEMBL7966117 | 0.82 | RAF1 (0.48) | MEN1RAB9AKMT2ANPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | disclosed |