Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | HTR1B | P28222 | 1/20 | 0.48 |
| ▸ | HTR1F | P30939 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | MERTK | Q12866 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30040346 | 0.95 | HTR1A (0.50) | ALDH1A1NPSR1SMN1; SMN2ATMHTR1A | |
| SCHEMBL23467071 | 0.90 | ALDH1A1 (0.50) | ALDH1A1NPSR1SMN1; SMN2ATMHTR1A | |
| SCHEMBL24338759 | 0.89 | HTR1A (0.46) | ALDH1A1HTR1AHTR1BHTR1FHPGD | |
| SCHEMBL31403635 | 0.87 | RPS6KB1 (0.48) | ALDH1A1NPSR1SMN1; SMN2ATMHTR1A | |
| SCHEMBL24339264 | 0.86 | HTR1A (0.43) | ALDH1A1NPSR1SMN1; SMN2ATMHTR1A | |
| SCHEMBL30174436 | 0.86 | HTR1A (0.43) | ALDH1A1NPSR1SMN1; SMN2ATMHTR1A | |
| SCHEMBL7419168 | 0.85 | HCAR3 (0.56) | ALDH1A1HTR1AHTR1BHTR1FHPGD | |
| SCHEMBL24900263 | 0.84 | RXRA (0.50) | ALDH1A1NPSR1SMN1; SMN2ATMHTR1A | |
| SCHEMBL3605908 | 0.84 | HTR1A (0.44) | ALDH1A1NPSR1SMN1; SMN2ATMHTR1A | |
| SCHEMBL904780 | 0.84 | CYP11B1 (0.47) | ALDH1A1NPSR1SMN1; SMN2ATMHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6262040-B1 | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the production of tumor necrosis factor (TNF) | PFIZER INC | 2001-07-17 | — | — | US | disclosed |
| CN-1234031-A | Indazole derivatives and their use as inhibitors of phosphodiesterase (PDE) type IV and the prodn. of tumor necrosis factor (TNF) | PFIZER (US) | 1999-11-03 | — | — | CN | disclosed |