Sugi Predict

Sugi Predict / Compounds / SCHEMBL797228

SCHEMBL797228

SCHEMBL797228

CC(C)(C)OC(=O)N1CCC(N2CCCC(O)C2=O)CC1

nearest known ligand 0.49

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ FPR2 P25090 2/20 0.49
▸ HPGD P15428 1/20 0.48
▸ TP53 P04637 1/20 0.47
▸ EPHX1 P07099 1/20 0.46
▸ KDM4E B2RXH2 1/20 0.45
▸ MAPT P10636 1/20 0.45
▸ THRB P10828 1/20 0.45
▸ HCAR1 Q9BXC0 1/20 0.45
▸ GPR119 Q8TDV5 4/20 0.43
▸ RECQL P46063 1/20 0.43
▸ PTPN2 P17706 1/20 0.42
▸ PTPN1 P18031 1/20 0.42
▸ PTPN6 P29350 1/20 0.42
▸ CTSD P07339 1/20 0.41
▸ CTSE P14091 1/20 0.41
▸ BACE1 P56817 1/20 0.41
▸ USP2 O75604 1/20 0.41
▸ SMN1; SMN2 Q16637 1/20 0.41
▸ ALDH1A1 P00352 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL797229 1.00 FPR2 (0.49) FPR2HPGDTP53EPHX1KDM4E
SCHEMBL15022876 0.92 FPR2 (0.54) FPR2HPGDTP53EPHX1KDM4E
SCHEMBL789114 0.92 FPR2 (0.54) FPR2HPGDTP53EPHX1KDM4E
SCHEMBL23336156 0.92 FPR2 (0.54) FPR2HPGDTP53EPHX1KDM4E
SCHEMBL794429 0.85 FPR2 (0.48) FPR2HPGDTP53EPHX1KDM4E
SCHEMBL794430 0.85 FPR2 (0.48) FPR2HPGDTP53EPHX1KDM4E
SCHEMBL15022787 0.85 FPR2 (0.51) FPR2HPGDTP53EPHX1KDM4E
SCHEMBL22720456 0.81 HPGD (0.50) FPR2HPGDTP53EPHX1KDM4E
SCHEMBL15044985 0.81 FPR2 (0.54) FPR2HPGDTP53EPHX1KDM4E
SCHEMBL795879 0.80 TP53 (0.45) FPR2HPGDTP53EPHX1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12617782-B2 Pyridazinones as PARP7 inhibitors RIBON THERAPEUTICS, INC. (US) 2026-05-05 — — US disclosed
US-20240034728-A1 PYRIDAZINONES AS PARP7 INHIBITORS RIBON THERAPEUTICS, INC. 2024-02-01 — — US disclosed
US-11691969-B2 Pyridazinones as PARP7 inhibtors RIBON THERAPEUTICS, INC. (US) 2023-07-04 — — US disclosed
US-11691969-B2 Pyridazinones as PARP7 inhibtors RIBON THERAPEUTICS, INC. (US) 2023-07-04 — — US disclosed
US-11691969-B2 Pyridazinones as PARP7 inhibtors RIBON THERAPEUTICS, INC. (US) 2023-07-04 — — US disclosed
EP-4051384-A1 PYRIDAZINONES AS PARP7 INHIBITORS Ribon Therapeutics Inc. (US) 2022-09-07 — — EP disclosed
US-20210130342-A1 PYRIDAZINONES AS PARP7 INHIBITORS ANKURA TRUST COMPANY, LLC, AS COLLATERAL TRUSTEE 2021-05-06 — — US disclosed
US-20210130342-A1 PYRIDAZINONES AS PARP7 INHIBITORS ANKURA TRUST COMPANY, LLC, AS COLLATERAL TRUSTEE 2021-05-06 — — US disclosed
WO-2021087025-A1 PYRIDAZINONES AS PARP7 INHIBITORS RIBON THERAPEUTICS, INC. (US) 2021-05-06 — — WO disclosed
WO-2021087025-A1 PYRIDAZINONES AS PARP7 INHIBITORS RIBON THERAPEUTICS, INC. (US) 2021-05-06 — — WO disclosed
US-20140256756-A1 PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS ARRAY BIOPHARMA, INC. 2014-09-11 — — US disclosed
US-8754226-B2 Piperidinyl-substituted lactams as GPR119 modulators ARRAY BIOPHARMA INC. (US) 2014-06-17 — — US disclosed
EP-2616074-A1 PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS Array Biopharma, Inc. (US) 2013-07-24 — — EP disclosed
US-20130184257-A1 PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS ARRAY BIOPHARMA, INC. 2013-07-18 — — US disclosed
US-20130158009-A1 PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS ARRAY BIOPHARMA, INC. 2013-06-20 — — US disclosed
WO-2013066869-A1 PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS ARRAY BIOPHARMA INC. (US) 2013-05-10 — — WO disclosed
EP-2571864-A1 PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS Array Biopharma, Inc. (US) 2013-03-27 — — EP disclosed
WO-2012037393-A1 PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS ARRAY BIOPHARMA INC. (US) 2012-03-22 — — WO disclosed
WO-2011146335-A1 PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS ARRAY BIOPHARMA INC. (US) 2011-11-24 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140256756-A1 PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS GPR119, GPR139, GLP1R FPR2 142/4885HPGD 3582/4885TP53 4810/4885
US-20210130342-A1 PYRIDAZINONES AS PARP7 INHIBITORS PARP2, PARP1, PARP4 FPR2 2873/4885HPGD 463/4885TP53 302/4885
US-20130158009-A1 PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS GPR119, GPR139, GPR39 FPR2 328/4885HPGD 3997/4885TP53 4790/4885
US-12617782-B2 Pyridazinones as PARP7 inhibitors PARP3, PARP2, PARP1 FPR2 3139/4885HPGD 668/4885TP53 848/4885
US-20130184257-A1 PIPERIDINYL-SUBSTITUTED LACTAMS AS GPR119 MODULATORS GPR119, GPR139, GPR180 FPR2 192/4885HPGD 3489/4885TP53 4756/4885
US-11691969-B2 Pyridazinones as PARP7 inhibtors PARP2, PARP1, PARP4 FPR2 4408/4885HPGD 471/4885TP53 199/4885
US-20240034728-A1 PYRIDAZINONES AS PARP7 INHIBITORS PARP2, PARP1, PARP4 FPR2 2873/4885HPGD 463/4885TP53 302/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.