Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 9/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 9/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 8/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.31 |
| ▸ | EDNRB | P24530 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7083169 | 0.86 | ADRA1A (0.40) | ADRA1AADRA1BADRA1DHRH1ATM | |
| SCHEMBL7083166 | 0.86 | ADRA1A (0.40) | ADRA1AADRA1BADRA1DHRH1ATM | |
| SCHEMBL7075810 | 0.86 | ADRA1A (0.40) | ADRA1AADRA1BADRA1DHRH1ATM | |
| SCHEMBL6082094 | 0.80 | ADRA1A (0.52) | ADRA1AADRA1BADRA1DHRH1ATM | |
| SCHEMBL6959819 | 0.80 | ADRA1A (0.52) | ADRA1AADRA1BADRA1DHRH1ATM | |
| SCHEMBL7095750 | 0.80 | ADRA1A (0.52) | ADRA1AADRA1BADRA1DHRH1ATM | |
| SCHEMBL7976303 | 0.79 | ADRA1A (0.38) | ADRA1AADRA1BADRA1DHRH1HCRTR2 | |
| SCHEMBL7976298 | 0.79 | ADRA1A (0.38) | ADRA1AADRA1BADRA1DHRH1HCRTR2 | |
| SCHEMBL7972575 | 0.79 | MGLL (0.39) | — | |
| SCHEMBL7874288 | 0.76 | CYP19A1 (0.37) | ADRA1AADRA1BADRA1DHRH1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6228870-B1 | BENIGN PROSTATIC HYPERPLASIA; REDUCTION OF HYPOTENSION SIDE EFFECT | MERCK & CO., INC. | 2001-05-08 | — | — | US | claimed |
| US-6228870-B1 | BENIGN PROSTATIC HYPERPLASIA; REDUCTION OF HYPOTENSION SIDE EFFECT | MERCK & CO., INC. | 2001-05-08 | — | — | US | disclosed |