Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 7/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.46 |
| ▸ | TEK | Q02763 | 2/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7968137 | 0.89 | KDR (0.61) | KDRRIPK1TEKFLT1CA12 | |
| SCHEMBL7972209 | 0.87 | CA12 (0.51) | MEN1KMT2ALMNAKDRMAPT | |
| SCHEMBL7969844 | 0.86 | RAB9A (0.47) | MEN1KMT2ALMNAKDRMAPT | |
| SCHEMBL7975298 | 0.85 | MAPT (0.55) | MEN1KMT2ALMNAKDRMAPT | |
| SCHEMBL7974451 | 0.83 | MAPT (0.47) | MEN1KMT2ALMNAKDRMAPT | |
| SCHEMBL7970350 | 0.83 | MAPT (0.41) | MEN1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL7972214 | 0.80 | MAPT (0.44) | MEN1KMT2AKDRMAPTSMN1; SMN2 | |
| SCHEMBL7968196 | 0.78 | MAPT (0.51) | MEN1KMT2ALMNACYP3A4CYP2C19 | |
| SCHEMBL7971235 | 0.78 | MAPT (0.45) | MEN1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL7971214 | 0.77 | SMN1; SMN2 (0.46) | MEN1KMT2ALMNAKDRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | disclosed |