Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 7/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7972214 | 0.91 | MAPT (0.44) | CA12CA1CA2CA9MEN1 | |
| SCHEMBL7971235 | 0.91 | MAPT (0.45) | CA12CA1CA2CA9MEN1 | |
| SCHEMBL7969844 | 0.91 | RAB9A (0.47) | CA12CA1CA2CA9MEN1 | |
| SCHEMBL7974451 | 0.88 | MAPT (0.47) | CA12CA1CA2CA9MEN1 | |
| SCHEMBL7972714 | 0.87 | MEN1 (0.50) | CA12CA1CA2CA9MEN1 | |
| SCHEMBL7970350 | 0.87 | MAPT (0.41) | CA12CA1CA2CA9MEN1 | |
| SCHEMBL7971214 | 0.81 | SMN1; SMN2 (0.46) | CA12CA1CA2CA9MEN1 | |
| SCHEMBL7972711 | 0.80 | RAB9A (0.53) | NPC1SMN1; SMN2MAPTRAB9AKDR | |
| SCHEMBL7968918 | 0.79 | RAB9A (0.54) | MEN1KMT2ANPC1SMN1; SMN2MAPT | |
| SCHEMBL7975277 | 0.78 | RAB9A (0.55) | CA12CA1CA2CA9MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | disclosed |