Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | KDR | P35968 | 4/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | GRIK1 | P39086 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7972209 | 0.91 | CA12 (0.51) | MAPTMEN1KMT2AHTTKDR | |
| SCHEMBL7971214 | 0.91 | SMN1; SMN2 (0.46) | MAPTMEN1KMT2AHTTKDR | |
| SCHEMBL7971235 | 0.90 | MAPT (0.45) | MAPTMEN1KMT2AHTTCA12 | |
| SCHEMBL7972711 | 0.90 | RAB9A (0.53) | MAPTKDRSMN1; SMN2RAB9ANPC1 | |
| SCHEMBL7968137 | 0.87 | KDR (0.61) | KDRCA12CA1CA2CA9 | |
| SCHEMBL7968477 | 0.86 | KDR (0.41) | MAPTMEN1KMT2AHTTKDR | |
| SCHEMBL7975277 | 0.86 | RAB9A (0.55) | MAPTMEN1KMT2AHTTKDR | |
| SCHEMBL7969844 | 0.81 | RAB9A (0.47) | MAPTMEN1KMT2AHTTKDR | |
| SCHEMBL7972714 | 0.80 | MEN1 (0.50) | MAPTMEN1KMT2AKDRCA12 | |
| SCHEMBL7968563 | 0.80 | RAB9A (0.55) | MAPTMEN1KMT2ACA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | disclosed |