Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.46 |
| ▸ | RAB9A | P51151 | 7/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 5/20 | 0.45 |
| ▸ | HTT | P42858 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7972214 | 0.91 | MAPT (0.44) | SMN1; SMN2RAB9AMAPTNPC1KDR | |
| SCHEMBL7972711 | 0.91 | RAB9A (0.53) | SMN1; SMN2RAB9AMAPTNPC1KDR | |
| SCHEMBL7968137 | 0.88 | KDR (0.61) | KDRCA12CA1CA2CA9 | |
| SCHEMBL7971219 | 0.88 | RAB9A (0.48) | SMN1; SMN2RAB9AMAPTNPC1LMNA | |
| SCHEMBL7968477 | 0.87 | KDR (0.41) | SMN1; SMN2RAB9AMAPTNPC1LMNA | |
| SCHEMBL7975277 | 0.87 | RAB9A (0.55) | SMN1; SMN2RAB9AMAPTNPC1KDR | |
| SCHEMBL7968563 | 0.85 | RAB9A (0.55) | SMN1; SMN2RAB9AMAPTNPC1LMNA | |
| SCHEMBL7973003 | 0.81 | MEN1 (0.48) | SMN1; SMN2RAB9AMAPTNPC1LMNA | |
| SCHEMBL7972209 | 0.81 | CA12 (0.51) | SMN1; SMN2RAB9AMAPTNPC1LMNA | |
| SCHEMBL7964851 | 0.81 | CNR1 (0.55) | RAB9AMAPTNPC1KDRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009137404-A1 | UREA COMPOUNDS AS GAMMA SECRETASE MODULATORS | AMGEN INC. (US) | 2009-11-12 | — | — | WO | disclosed |